Services 4 — The Laboratory of Imunoregulation and Tcell Biology

One-step generation of T-cell receptor knock-in mice in the TCRβ locus

Description goes hereJana Bilanovic, Juliana Bortolatto, Susu Duan, Valgerdur Bjørnsdottir, A Katharina Teetz, Alexandra Thoms, Julian Fischbach, Fabian Schmidt, William A Nyberg, Harald Hartweger, Amelia Escolano, Paul G Thomas, Gabriel D Victora, Angelina M Bilate, Johanne T Jacobsen. EMBO Methods May 2026

Expression of Foxp3 by T follicular helper cells in end-stage germinal centers.

Jacobsen JT, Hu W, R Castro TB, Solem S, Galante A, Lin Z, Allon SJ, Mesin L, Bilate AM, Schiepers A, Shalek AK, Rudensky AY, Victora GD. Science. 2021 Jul

One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.

Jacobsen JT, Mesin L, Markoulaki S, Schiepers A, Cavazzoni CB, Bousbaine D, Jaenisch R, Victora GD. J Exp Med. 2018 Oct

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics.

Nakandakari-Higa S, Canesso MCC, Walker S, Chudnovskiy A, Jacobsen JT, Parigi SM, Fiedorczuk K, Fuchs E, Bilate AM, Pasqual G, Mucida D, Pritykin Y, Victora GD.bioRxiv. 2023 Mar

Clonal replacement sustains long-lived germinal centers primed by respiratory viruses

de Carvalho RVH, Ersching J, Barbulescu A, Hobbs A, Castro TBR, Mesin L, Jacobsen JT, Phillips BK, Hoffmann HH, Parsa R, Canesso MCC, Nowosad CR, Feng A, Leist SR, Baric RS, Yang E, Utz PJ, Victora GD. Cell. 2023 Jan

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD. Immunity. 2017 Jun

Share itVisualizing Antibody Affinity Maturation in Germinal Centers

Jeroen M J Tas , Luka Mesin, Giulia Pasqual, Sasha Targ, Johanne T Jacobsen, Yasuko M Mano, Casie S Chen, Jean-Claude Weill, Claude-Agnès Reynaud, Edward P Browne, Michael Meyer-Hermann, Gabriel D Victora Science 2016